閱讀文章

口服三烯生育醇對頭髮生長影響的臨床實驗(下)

[日期:2011-02-26] 來源:轉載  作者:佚名

Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers
補充三烯生育醇對頭髮生長的影響

研究結果與討論

三十八位有異常掉髮情況或禿頭的志願受試者參加了研究,口服三烯生育醇組有21名志願者(192女),安慰劑組(對照組)有17個志願者(全部為男性)。該研究的人口年齡介於 1859歲。受試者年齡範圍廣泛,因為掉髮是不受年齡之限制。年輕的成年人與老年人都會有受到掉髮問題的影響。此外,掉髮可能是由於營養缺乏和氧化壓力所導致,從而影響廣泛的年齡組。受試者掉髮問題大約有2~5年的時間。

研究開始前,針對受試組成員的頭髮數以及頭髮重量加以評估。
安慰劑組受試者的毛髮的平均數目基線為289.0 ± 98.3,而補充三烯生育醇組為284.8 ± 111.3。至於20股頭髮平均重量,安慰劑組受試者的毛髮的平均數目基線為0.1002克和 ±0.0639,而補充三烯生育醇組為0.0920 ± 0.0565克。比較兩組的兩個參數並沒有顯著差異(P> 0.05)。

三十五位受試者完成了整個研究,並評價補充三烯生育醇的效果。三名受試者中止研究,一位()是三烯生育醇組,和兩位安慰劑組。每個月記錄與訪視過程中,補充三烯生育醇的順從性是令人滿意的。兩組皆無嚴重藥物反應或有關的記錄。從而表明,持續8個月服用100毫克的生育三烯酚是可以忍受的。研究方案也被認為是令人滿意的,沒有偏差協定的記錄。

1顯示了受試者在基線,第4和第8個月的頭髮數量變化,以及髮量增加的百分比變化。顯而易見的是,三烯生育醇補充組,從基線到第8個月的時間,頭髮數量有逐漸增加,最後平均增幅超過 34%。相比之下,安慰劑組受試者沒有表現出任何明顯的髮量增加,約減少0.1%。杜克的事後檢驗表明(Tukey’s post-hoc test),補充三烯生育醇的受試者頭髮增加並無安慰劑效應。成對比較還表明,8個月的時間,補充三烯生育醇組和安慰劑組噢試者的頭髮數量有顯著差異。



研究結束時,對於頭髮數量增加的效果評估,有一個志願受試者例外。整體而言,8名志願者(40.0%)顯示頭髮增加了50%以上,1名志願(5.0%)有25%至50%的增幅,9名受試者(45.0%)有增加10%至25%,而1名受試者(5.0% )為頭髮增加不到10%。只有1名受試者(5.0%)髮量有些微減少。另一方面,在8個月後,在安慰劑組有8個志願者顯示有增加頭髮的數量,1名(6.7%),顯示超過 20%的增長,其餘 7名(46.7%),顯示微不足道(negligible)的增加。7名受試者(46.7%)頭髮減少。

然而,兩組的頭髮重量並沒有顯著增加。三烯生育醇補充組,平均百分比增重了5.9%的,而安慰劑組有輕微下降2.0%(見表 2)。研究結果之後,另行補充相關的研究顯示,抗氧化劑可能被用來控制雄性禿掉髮。


結論

總之,本試驗表明,補充三烯生育醇膠囊的受試者與安慰劑組相比,頭髮數量有增加。
一種可能的解釋,效果可能是由於強大的抗氧化活性的生育三烯醇,以幫助降低頭皮的脂質過氧化和氧化壓力。

參考資料

Akar A, Arca E, Erbil H, Akay C, Sayal A and Gur A R. (2002). Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata. Journal of Dermatological Science 29(2): 85–90.
Bradfield R B and Bailey M A. (1969). Hair root response to protein malnutrition. In W Montagna and R L Dobson (eds.). Biology of skin, hair growth, vol 9; 7. Oxford: Pergamon Press, 109–119.
Cash T F, Price V H and Savin R C. (1993). Psychological effects of androgenetic alopecia on women: comparisons with balding men and with female control subjects. Journal of the American Academy of Dermatology 29(4): 568–575.
Cash T F. (2001). The psychology of hair loss and its implications for patient care. Clinics in Dermatology 19(2): 161–166.
Van der Donk J, Hunfeld J A M, Passchier J, Knegt-Junk K J and Nieboer C. (1994). Quality of life and maladjustment associated with hair loss in women with alopecia androgenetica. Social Science & Medicine 38(1): 159–163.
Girat M, Cervello I, Nogues M R, Puerto A M, Ortin F, Argany N and Mallol J. (1996). Glutathione, glutathione S-transferase and reactive oxygen species of human scalp sebaceous glands in male pattern baldness. Journal of Investigative Dermatology 107(2): 154–158.
Hee C E. (2008). The involvement of ROS on androgen inducible TGF beta 1 regulation derived from dermal papilla cells; a suggestive implication of ROS on androgenetic alopecia. Journal of the American Academy of Dermatology 58(2) Suppl 2: AB84.
Hogan D J and Chamberlain M. (2000). Male pattern baldness. Southern Medical Journal 93(7): 657–662

Inui S, Fukuzato Y, Nakajima T, Yoshikawa K and Itami S. (2003). Identification of androgen-inducible TGF-β1 derived from dermal papilla cells as key mediator in androgebetic alopecia. Journal of Investigative Dermatology: symposium Proceedings 8(1): 69–71.
Koca R, Armutcu F, Altinyazar H and Gurel A. (2005). Evaluation of lipid peroxidation, oxidant/antioxidant status and serum nitric oxide levels in alopecia areata. Medical Science Monitor 11(6): 296–299. Kirk R E. (1968). Experimental design: Procedure for the behavioural science. CA, USA: Brooks/Cole Publishing Company.
Naziroglu M and Kokcam I. (2000). Antioxidants and lipid peroxidation status in the bllod of patients with alopecia. Cell Biochemistry and Function 18(3): 169–173.
Papas A M. (1999). Vitamin E: Tocopherols and tocotrienols. In A M Papas (ed.). Antioxidant status, diet, nutrition and health. Boca Raton, Fl: CRC Press, 189–210.
Price V H, Menefee E, Sanchez M, Ruane P and Kaufman K D. (2002). Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg daily. Journal of the American Academy of Dermatology 46(4): 517–523.
Rushton D H, Norris M J, Dover R and Busuttil N. (2002). Causes of hair loss and the developments in hair rejuvenation. International Journal of Cosmetic Science 24(1): 17–23.
Rushton D H, Ramsay I D, James K C, Norris M J and Gilkes J J H. (1990). Biochemical and trichological characterization of diffuse alopecia in women. British Journal of Dermatology 123(2): 187–197.
Rushton D H. (2002). Nutritional factors and hair loss. Clinical and Experimental Dermatology 27(5): 396–404.
Serbinova E, Kagan V, Han D and Packer L. (1991). Free radical recycling and intramembrane mobility in the antioxidant properties of alpha tocopherol and alpha tocotrienol. Free Radical Biology and Medicine 10(5): 263–275.
Sims R T. (1968). The measurement of hair growth as an index of protein synthesis in malnutrition. British Journal of Nutrition 22: 229–236.
Theriault A, Chao J T, Wang Q, Gapor A and Adeli K. (1999). Tocotrienol: A review of its therapeutic potential. Clinical Biochemistry 32(5): 309–319.
Traber M G, Podda M, Weber C, Thiele J, Rallis M and Packer L. (1997). Diet-derived and topically applied tocotrienols accumulative in skin and protect the tissue against ultraviolet light-induced oxidative stress. Asia Pacific journal of Clinical Nutrition 6(1): 63–67.



閱讀:
錄入:站長

上一篇:口服三烯生育醇對頭髮生長影響的臨床實驗(中)
下一篇:有助於頭髮生長的各類氨基酸
推介文章
聯絡方式
 
脫髮相關藥物
高濃度 男用生髮水
最強防脫髮洗頭水 Regenepure
Nizoral 最受歡迎防脫洗髮水
JASON 頭髮變濃密洗頭水
落建生髮水
神奇假髮 一用即變茂密 Toppik
 
頭髮用品小舖
> 進入店舖首頁 <
新版商城
限時特價
全面升級
反應熱烈 多買多平